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Pritzker Olsen Law Firm Food Safety Blog
Pritzker Olsen attorneys have appeared on CBS News, Fox news, and numerous local television stations throughout the country. They have recovered millions for victims of food poisoning outbreaks. To contact our law firm, please call 1-888-377-8900 (toll free) or submit our free consultation form.
New Technique to Test DNA of E. coli Bacteria
“It used to take three months to score one gene individually,” said Thomas Whittam, Hannah Distinguished Professor at the National Food Safety and Toxicology Center at MSU. “Now, we are working on a new, more rapid system that can do thousands of genes per day.”
In a new study released in the Monday edition of the Proceedings of the National Academy of Sciences, “Variation in Virulence Among Clades of Escherichia coli O157:H7 Associated With Disease Outbreaks,” Whittam and his co-authors looked at the DNA of more than 500 strains of a particularly dangerous member of the E. coli family, O157:H7. In collaboration with David Alland of the University of Medicine and Dentistry of New Jersey, Whittam discovered that individual bacteria could be separated into nine major groups, called clades.
E coli makes people sick because they produce toxins, called Shiga toxins. These toxins block protein synthesis, an essential cellular function, particularly in the kidneys. What Whittam found was that the different clades produced different kinds of Shiga toxins in varying amounts based on their DNA.
“For the first time, we know why some outbreaks cause serious infections and diseases and others don’t,” Whittam said. “The different E. coli groups produce different toxins.”
Rapid genetic characterization also opens up a new world of possibilities for identifying the bacterial culprits in outbreaks and finding out where they originated.
“This is the first time anyone has been able to classify very closely related groups,” Whittam said. “This is also the first time we can tell the differences in how they cause disease.”
Whittam also has plans to use this methodology to study other bacterial strains, like Shigella, a major cause of diarrhea around the world. “This new equipment can be used to identify hundreds of thousands of pathogenic bacteria,” Whittam said.
Source: Michigan State University press release.
Posted March 2008.
Labels: DNA testing
Food Poisoning Lawyer Fred Pritzker has appeared on national television and has been quoted by national publications, including The New York Times, The Wall Street Journal, Associated Press and Lawyers USA. He has been named a "Super Lawyer" by Law and Politics magazine. He is also listed in the current edition of The Best Lawyers in America. To contact Fred Pritzker about a food poisoning lawsuit or food safety advocacy, please call 1-888-377-8900 (toll free) or submit the firm's free consultation form.
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