Welcome to the Pritzker | Ruohonen Food Safety Blog

Is E. coli O157:H7 Becoming More Virulent?

A phylogenetic analysis of E. coli O157:H7 has found that recombination or recurrent mutation has contributed to the evolution of E. coli O157:H7 into more virulent strains. The research was prompted by several recent outbreaks involving E. coli O157:H7 (e.g., 2006 spinach E. coli outbreak) that were “associated with more severe disease, as defined by higher hemolytic uremic syndrome and hospitalization frequencies, suggesting that increased virulence has evolved.”

500 E. coli O157:H7 clinical strains were analyzed and separated into 9 distinct clades:
Differences were observed between clades in the frequency and distribution of Shiga toxin genes and in the type of clinical disease reported. Patients with hemolytic uremic syndrome were significantly more likely to be infected with clade 8 strains, which have increased in frequency over the past 5 years. Genome sequencing of a spinach outbreak strain, a member of clade 8, also revealed substantial genomic differences. These findings suggest that an emergent subpopulation of the clade 8 lineage has acquired critical factors that contribute to more severe disease.
Read the results of this study published in Proceedings of the National Academy of Sciences of the United States of America.

As part of this study, Thomas Whittam, Hannah Distinguished Professor at the National Food Safety and Toxicology Center at Michigan State University and David Alland of the University of Medicine and Dentistry of New Jersey, two co-authors of the study, developed a new technique to test E. coli O157:H7 DNA.

Posted March 2008.

Labels: , ,



Free Case Consultation





Logos

Firm News

Fred Pritzker Listed in The Best Lawyers in America

Fred Pritzker has been notified that he will again be listed in The Best Lawyers in America.

 

Taste of Chicago

Pritzker | Ruohonen attorney Rich Ruohonen is managing attorney for our Taste of Chicago / Pars Cove Salmonella cases, which involve a Salmonella outbreak with over 180 confirmed cases of Salmonella. Contact Rich Ruohonen regarding these cases at 1-888-377-8900 (toll-free).

 

E. coli Wrongful Death Settlement

We have recently settled a number of E. coli cases involving victims of various E. coli outbreaks, including a wrongful death claim.

 

Attorney Rich Ruohonen Has Article Published

Rich Ruohonen's recently published article addresses effective cross examination of the defence neuropsychologist.

Foodborne Outbreaks